Anti-CDA Antibody Picoband®

Cytidine deaminase is an enzyme that in humans is encoded by the CDA gene. This gene is mapped to 1p36.12. It encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias.

A synthetic peptide corresponding to a sequence at the N-terminus of human CDA, which shares 63% amino acid (aa) sequence identity with both mouse and rat CDA.

1. Demontis, S., Terao, M., Brivio, M., Zanotta, S., Bruschi, M., Garattini, E. Isolation and characterization of the gene coding for human cytidine deaminase. Biochim. Biophys. Acta 1443: 323-333, 1998. 2. Fitzgerald, S. M., Goyal, R. K., Osborne, W. R. A., Roy, J. D., Wilson, J. W., Ferrell, R. E. Identification of functional single nucleotide polymorphism haplotypes in the cytidine deaminase promoter. Hum. Genet. 119: 276-283, 2006. 3. Jahns-Streubel, G., Reuter, C., Auf der Landwehr, U., Unterhalt, M., Schleyer, E., Wormann, B., Buchner, T., Hiddemann, W. Activity of thymidine kinase and of polymerase alpha as well as activity and gene expression of deoxycytidine deaminase in leukemic blasts are correlated with clinical response in the setting of granulocyte-macrophage colony-stimulating factor-based priming before and during TAD-9 induction therapy in acute myeloid leukemia. Blood 90: 1968-1976, 1997.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.