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Anti-Grancalcin/GCA Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Grancalcin is a protein that in humans is encoded by the GCA gene. This gene is mapped to 2q24.2. This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.

Synonyms

Grancalcin; GCA; GCL

Gene Name

GCA

Gene ID

25801

UniProt

P28676

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human Grancalcin/GCA recombinant protein (Position: A42-I217) .

Clonality

Polyclonal

Tissue Specificity

Detected in neutrophils and macrophages (at protein level) . Highly expressed in bone marrow.

Applications

Flow Cytometry

Field of Research

Amino Acid Metabolism, Amino Acids, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Calcium-binding protein that may play a role in the adhesion of neutrophils to fibronectin. May play a role in the formation of focal adhesions.

References & Citations

1. Boyhan A, Casimir CM, French JK, Teahan CG, Segal AW (Mar 1992) . Molecular cloning and characterization of grancalcin, a novel EF-hand calcium-binding protein abundant in neutrophils and monocytes. J Biol Chem. 267 (5) : 2928–33. 2. Teahan CG, Totty NF, Segal AW (Oct 1992) . Isolation and characterization of grancalcin, a novel 28 kDa EF-hand calcium-binding protein from human neutrophils. Biochem J. 286. (Pt 2) : 549–54. 3. Hansen C, Tarabykina S, la Cour JM, Lollike K, Berchtold MW (Jun 2003) . The PEF family proteins sorcin and grancalcin interact in vivo and in vitro. FEBS Lett. 545 (2-3) : 151–4. 4. Entrez Gene: GCA grancalcin, EF-hand calcium binding protein.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

123799 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Grancalcin

Subcellular Location

Cytoplasm. Cytoplasmic granule membrane. Peripheral membrane protein. Cytoplasmic side.

Protein Name

Vinculin

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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