Anti-CD272/BTLA Antibody Picoband® Fluoro550 Conjugated

Product Specifications

Background

B- and T-lymphocyte attenuator is a protein that in humans is encoded by the BTLA gene. BTLA has also been designated as CD272 (cluster of differentiation 272) . This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an increased risk of rheumatoid arthritis. BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 and CTLA4, BTLA interacts with a B7 homolog, B7H4.

Synonyms

B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein; CD272; BTLA

Gene Name

BTLA

Gene ID

151888

UniProt

Q7Z6A9

Host

Rabbit

Reactivity

Human, Mouse

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human CD272/BTLA.

Clonality

Polyclonal

Tissue Specificity

Wide tissue distribution (highest in the pancreas and very low in brain) . Closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls.

Applications

Flow Cytometry

Field of Research

Adaptive Immunity, Immunology, T Cells

Purification

Immunogen affinity purified.

Form

Liquid

Function

Lymphocyte inhibitory receptor which inhibits lymphocytes during immune response.

References & Citations

1. Watanabe N, Gavrieli M, Sedy JR, Yang J, Fallarino F, Loftin SK, Hurchla MA, Zimmerman N, Sim J, Zang X, Murphy TL, Russell JH, Allison JP, Murphy KM (July 2003) . 2. BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nature Immunology. 4 (7) : 670–9. 3. Entrez Gene: BTLA B and T lymphocyte associated.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

65411 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

B and T lymphocyte associated

Subcellular Location

Membrane.

Protein Name

Glutamate decarboxylase 2

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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Anti-CD272/BTLA Antibody Picoband® Fluoro550 Conjugated

Product Specifications

Background

Synonyms

Gene Name

Gene ID

UniProt

Host

Reactivity

Cross Reactivity

Immunogen

Clonality

Tissue Specificity

Applications

Field of Research

Purification

Form

Function

References & Citations

Storage Conditions

Calculated Molecular Weight

Specificity

Applications Notes

Gene Name Synonym

Subcellular Location

Protein Name

Isotype

Contents

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