Anti-Beta 2 Microglobulin B2M Antibody Picoband® (monoclonal, 2H10) Fluoro647 Conjugated
Product Specifications
Background
Beta-2 microglobulin also known as B2M is a component of MHC class I molecules, which are present on all nucleated cells (excludes red blood cells) . In humans, the beta-2-microglobulin protein is encoded by the B2M gene. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.
Synonyms
Beta-2-microglobulin; Beta-2-microglobulin form pI 5.3; B2M; CDABP0092, HDCMA22P
Gene Name
B2M
Gene ID
567
UniProt
P61769
Host
Mouse
Reactivity
Human, Monkey
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E.coli-derived human Beta 2 Microglobulin recombinant protein (Position: Q22-M119) . Human Beta 2 Microglobulin shares 69.4% and 74.5% amino acid (aa) sequence identity with mouse and rat Beta 2 Microglobulin, respectively.
Clonality
Monoclonal
Clone
Clone: 2H10
Tissue Specificity
Expressed in all tissues tested including spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.
Applications
Flow Cytometry
Field of Research
Cancer, Cardiovascular, Serum Proteins, Tumor Biomarkers
Purification
Immunogen affinity purified.
Form
Liquid
Function
Component of the class I major histocompatibility complex (MHC) . Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553) .
References & Citations
1. Güssow D, Rein R, Ginjaar I, Hochstenbach F, Seemann G, Kottman A, Ploegh HL (1 November 1987) . The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit. J. Immunol. 139 (9) : 3132–8. 2. Munshi NC, Longo DL, Anderson KC (2011) . Chapter 111: Plasma Cell Disorders. In Loscalzo J, Longo DL, Fauci AS, Dennis LK, Hauser SL. Harrison's Principles of Internal Medicine (18th ed.) . McGraw-Hill Professional. pp. 936–44. 3. Pignone M, Nicoll D; McPhee SJ (2004) . Pocket guide to diagnostic tests (4th ed.) . New York: McGraw-Hill. p. 191. ISBN 0-07-141184-4.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Beta-2-microglobulin
Subcellular Location
Secreted
Protein Name
Membrane cofactor protein
Isotype
Mouse IgG2b
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS1189182-01 1 mg (E-Coli)
Recombinant Yersinia pseudotuberculosis serotype O:1b NADH-quinone oxidoreductase subunit H (nuoH), partial
Sign In for Pricing
View Details MBS1189182-02 1 mg (Yeast)
Recombinant Yersinia pseudotuberculosis serotype O:1b NADH-quinone oxidoreductase subunit H (nuoH), partial
Sign In for Pricing
View Details 
FAB150MFV450 0.1 mL
Mouse Monoclonal CCR2 Antibody (48607) [mFluor Violet 450 SE]
Sign In for Pricing
View Details 
bsm-62910R-BF488 100 µL
CD10 Recombinant Antibody, AbBy Fluor™ 488 Conjugated
Sign In for Pricing
View Details