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Anti-Beta 2 Microglobulin B2M Antibody Picoband® (monoclonal, 2H10) Fluoro550 Conjugated

Product Specifications

Background

Beta-2 microglobulin also known as B2M is a component of MHC class I molecules, which are present on all nucleated cells (excludes red blood cells) . In humans, the beta-2-microglobulin protein is encoded by the B2M gene. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.

Synonyms

Beta-2-microglobulin; Beta-2-microglobulin form pI 5.3; B2M; CDABP0092, HDCMA22P

Gene Name

B2M

Gene ID

567

UniProt

P61769

Host

Mouse

Reactivity

Human, Monkey

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E.coli-derived human Beta 2 Microglobulin recombinant protein (Position: Q22-M119) . Human Beta 2 Microglobulin shares 69.4% and 74.5% amino acid (aa) sequence identity with mouse and rat Beta 2 Microglobulin, respectively.

Clonality

Monoclonal

Clone

Clone: 2H10

Tissue Specificity

Expressed in all tissues tested including spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.

Applications

Flow Cytometry

Field of Research

Cancer, Cardiovascular, Serum Proteins, Tumor Biomarkers

Purification

Immunogen affinity purified.

Form

Liquid

Function

Component of the class I major histocompatibility complex (MHC) . Involved in the presentation of peptide antigens to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell surface (total protein levels do not change), probably leading to defects in class I antigen presentation (PubMed:25356553) .

References & Citations

1. Güssow D, Rein R, Ginjaar I, Hochstenbach F, Seemann G, Kottman A, Ploegh HL (1 November 1987) . The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit. J. Immunol. 139 (9) : 3132–8. 2. Munshi NC, Longo DL, Anderson KC (2011) . Chapter 111: Plasma Cell Disorders. In Loscalzo J, Longo DL, Fauci AS, Dennis LK, Hauser SL. Harrison's Principles of Internal Medicine (18th ed.) . McGraw-Hill Professional. pp. 936–44. 3. Pignone M, Nicoll D; McPhee SJ (2004) . Pocket guide to diagnostic tests (4th ed.) . New York: McGraw-Hill. p. 191. ISBN 0-07-141184-4.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Beta-2-microglobulin

Subcellular Location

Secreted

Protein Name

Membrane cofactor protein

Isotype

Mouse IgG2b

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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