Anti-IL22 Antibody Picoband® (monoclonal, 7F2) Fluoro647 Conjugated

Product Specifications

Background

Interleukin-22 (IL-22), also known as ILTIF, is protein that in humans is encoded by the IL22 gene. IL-22 a member of a group of cytokines called the IL-10 family or IL-10 superfamily, a class of potent mediators of cellular inflammatory responses. Using FISH, the IL22 gene is mapped to chromosome 12q15, close to the IFNG and the herpesvirus saimiri-induced AK155 genes. IL-22 can contribute to immune disease through the stimulation of inflammatory responses, S100s and defensins. It also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. In some contexts, the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by the often co-expressed cytokine IL-17A.

Synonyms

Interleukin-22; IL-22; Cytokine Zcyto18; IL-10-related T-cell-derived-inducible factor; IL-TIF; IL22; ILTIF, ZCYTO18; UNQ3099/PRO10096

Gene Name

IL22

Gene ID

50616

UniProt

Q9GZX6

Host

Mouse

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human IL-22 recombinant protein (Position: A34-I179) . Human IL-22 shares 81.4% amino acid (aa) sequence identity with mouse IL-22.

Clonality

Monoclonal

Clone

Clone: 7F2

Applications

Flow Cytometry

Field of Research

Adapters, Cytokines, Immunology, Innate Immunity, Interleukins, Macrophage/Inflammation, Signal Transduction, Transmembrane

Purification

Immunogen affinity purified.

Form

Liquid

Function

Cytokine that contributes to the inflammatory response in vivo.

References & Citations

1. Dumoutier, L., Van Roost, E., Ameye, G., Michaux, L., Renauld, J.-C. IL-TIF/IL-22: genomic organization and mapping of the human and mouse genes. Genes Immunity 1: 488-494, 2000. 2. Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A (2001) . Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 19: 683–765.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

Interleukin 22

Subcellular Location

Secreted.

Isotype

Mouse IgG1

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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Anti-IL22 Antibody Picoband® (monoclonal, 7F2) Fluoro647 Conjugated

Product Specifications

Background

Synonyms

Gene Name

Gene ID

UniProt

Host

Reactivity

Cross Reactivity

Immunogen

Clonality

Clone

Applications

Field of Research

Purification

Form

Function

References & Citations

Storage Conditions

Specificity

Applications Notes

Gene Name Synonym

Subcellular Location

Isotype

Contents

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