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Anti-CD137/Tnfrsf9 Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

CD137 is a member of the tumor necrosis factor (TNF) receptor family. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.

Synonyms

Tumor necrosis factor receptor superfamily member 9; 4-1BB ligand receptor; T-cell antigen 4-1BB; CD137; Tnfrsf9; Cd137; Ila; Ly63

Gene Name

Tnfrsf9

Gene ID

21942

UniProt

P20334

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived mouse CD137 recombinant protein (Position: V24-L187) .

Clonality

Polyclonal

Tissue Specificity

Expressed on the surface of activated T-cells.

Applications

Flow Cytometry

Field of Research

Apoptosis, Associated Proteins, Cancer, Cell Biology, Cell Death, Cell Type Markers, Cytokines, Hematopoietic Progenitors, Immunology, Innate Immunity, Lymphoid, Receptors, Stem Cells, T Lymphocytic Lineage, TNF Superfamily, Tumor Immunology

Purification

Immunogen affinity purified.

Form

Liquid

Function

Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.

References & Citations

1. McNamara, J. O., II, Kolonias, D., Pastor, F., Mittler, R. S., Chen, L., Giangrande, P. H., Sullenger, B., Gilboa, E. Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice. J. Clin. Invest. 118: 376-386, 2008. 2. Munks, M. W., Mourich, D. V., Mittler, R. S., Weinberg, A. D., Hill, A. B. 4-1BB and OX40 stimulation enhance CD8 and CD4 T-cell responses to a DNA prime, poxvirus boost vaccine.Immunology 112: 559-566, 2004. 3. Seo, S. K., Choi, J. H., Kim, Y. H., Kang, W. J., Park, H. Y., Suh, J. H., Choi, B. K., Vinay, D. S., Kwon, B. S. 4-1BB-mediated immunotherapy of rheumatoid arthritis. Nature Med. 10: 1088-1094, 2004. Note: Erratum: Nature Med. 10: 1261 only, 2004.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

TNF receptor superfamily member 9

Subcellular Location

Membrane; Single-pass type I membrane protein.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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