Anti-TNF Receptor I/TNFRSF1A Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), also known as TNFR1, is a protein that in humans is encoded by the TNFRSF1A gene. The protein encoded by this gene is a member of the Tumor necrosis factor receptor superfamily, which also contains TNFRSF1B. The TNFR1 gene is mapped to 12pter-cen. It encodes a protein of 455 amino acids. And this receptor can activate the transcription factor NF-κB, mediate apoptosis, and function as a regulator of inflammation.
Synonyms
Tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor 1; TNF-R1; Tumor necrosis factor receptor type I; TNF-RI; TNFR-I; p55; p60; CD120a; Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1; TBPI; TNFRSF1A; TNFAR; TNFR1
Gene Name
TNFRSF1A
Gene ID
7132
UniProt
P19438
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E. coli-derived human TNF Receptor I recombinant protein (Position: I22-T211) .
Clonality
Polyclonal
Tissue Specificity
Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B- cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus.
Applications
Flow Cytometry
Field of Research
Antiviral Signaling, Apoptosis, Associated Proteins, Cancer, Cell Biology, Cell Death, Growth Factors/Hormones, Immune System Diseases, Immunology, Receptors, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
References & Citations
1. Baker E, Chen LZ, Smith CA, Callen DF, Goodwin R, Sutherland GR (Nov 1991) . Chromosomal location of the human tumor necrosis factor receptor genes. Cytogenet Cell Genet 57 (2-3) : 117–8. 2. Schall TJ, Lewis M, Koller KJ, Lee A, Rice GC, Wong GH, Gatanaga T, Granger GA, Lentz R, Raab H, et al. (Jun 1990) . Molecular cloning and expression of a receptor for human tumor necrosis factor. Cell 61 (2) : 361–70.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
50495 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
TNF receptor superfamily member 1A
Subcellular Location
Cell membrane.
Protein Name
Tumor necrosis factor receptor superfamily member 1A
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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