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Anti-RASAL1/RASAL1 Antibody Picoband®

Selected Variant

A06423-2

Size: 100 µg/Vial

Boster Bio Anti-RASAL1/RASAL1 Antibody Picoband® catalog # A06423-2. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. And it is mapped to 12q24.13. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described.

Synonyms

RasGAP-activating-like protein 1; RAS protein activator like 1

Gene Name

RASAL1

Gene ID

8437

UniProt

O95294

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human RASAL1 recombinant protein (Position: D721-A798) .

Clonality

Polyclonal

Tissue Specificity

Highly expressed in thyroid and adrenal medulla, lower expression in brain, spinal cord and trachea (PubMed:9751798) . Expressed in melanocytes (PubMed:23999003) .

Applications

ELISA, IHC, WB

Field of Research

Cancer, G Protein Signaling, Oncoproteins/Suppressors, Regulators, Signal Transduction, Signaling Pathway, Small G Proteins, Tumor Suppressors

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Probable inhibitory regulator of the Ras-cyclic AMP pathway (PubMed:9751798) . Plays a role in dendrite formation by melanocytes (PubMed:23999003) .

References & Citations

1. Allen, M., Chu, S., Brill, S., Stotler, C., Buckler, A. Restricted tissue expression pattern of a novel human rasGAP-related gene and its murine ortholog. Gene 218: 17-25, 1998. 2. Bechtel, W., McGoohan, S., Zeisberg, E. M., Muller, G. A., Kalbacher, H., Salant, D. J., Muller, C. A., Kalluri, R., Zeisberg, M. Methylation determines fibroblast activation and fibrogenesis in the kidney. Nature Med. 16: 544-550, 2010. 3. Jin, H., Wang, X., Ying, J., Wong, A. H. Y., Cui, Y., Srivastava, G., Shen, Z.-Y., Li, E.-M., Zhang, Q., Jin, J., Kupzig, S., Chan, A. T. C., Cullen, P. J., Tao, Q. Epigenetic silencing of a Ca (2+) -regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers. Proc. Nat. Acad. Sci. 104: 12353-12358, 2007.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

90 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

RAS protein activator like 1

Isotype

Rabbit IgG

Contents

243

Price

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