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Anti-PTCRA Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

This PTCRA gene is mapped to 6p21.1. The protein encoded by this gene is a single-pass type I membrane protein that is found in immmature but not mature T-cells. Along with TCRB and CD3 complex, the encoded protein forms the pre-T-cell receptor complex, which regulates early T-cell development. Four transcript variants encoding different isoforms have been found for this gene.

Synonyms

Pre T-cell antigen receptor alpha; pT-alpha; pTa; pT-alpha-TCR; PTCRA

Gene Name

PTCRA

Gene ID

171558

UniProt

Q6ISU1

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human PTCRA recombinant protein (Position: T24-T143) .

Clonality

Polyclonal

Tissue Specificity

Expressed in immature but not mature T-cells. Also found in CD34+ cells from peripheral blood, CD34+ precursors from umbilical cord blood and adult bone marrow.

Applications

Flow Cytometry

Field of Research

Hematopoietic Progenitors, Lymphoid, Stem Cells, T Lymphocytic Lineage

Purification

Immunogen affinity purified.

Form

Liquid

Function

The pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) regulates early T-cell development. .

References & Citations

1. Aifantis, I., Borowski, C., Gounari, F., Lacorazza, H. D., Nikolich-Zugich, J., von Boehmer, H. A critical role for the cytoplasmic tail of pT-alpha in T lymphocyte development. Nature Immun. 3: 483-488, 2002. Note: Erratum: Nature Immun. 3: 591 only, 2002. 2. Del Porto, P., Bruno, L., Mattei, M.-G., von Boehmer, H., Saint-Ruf, C. Cloning and comparative analysis of the human pre-T-cell receptor alpha-chain gene. Proc. Nat. Acad. Sci. 92: 12105-12109, 1995. 3. Saint-Ruf, C., Lechner, O., Feinberg, J., von Boehmer, H. Genomic structure of the human pre-T cell receptor alpha chain and expression of two mRNA isoforms. Europ. J. Immun. 28: 3824-3831, 1998.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

41409 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Pre T cell antigen receptor alpha

Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Name

Protein NDRG3

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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