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Anti-EML4 Antibody Picoband® Fluoro594 Conjugated

Product Specifications

Background

Echinoderm microtubule-associated protein-like 4 is a protein that in humans is encoded by the EML4gene. This gene is a member of the echinoderm microtubule associated protein-like family, and it mapped to 2p21. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants.

Synonyms

Echinoderm microtubule-associated protein-like 4; EMAP-4; Restrictedly overexpressed proliferation-associated protein; Ropp 120; EML4; C2orf2; EMAPL4

Gene Name

EML4

Gene ID

27436

UniProt

Q9HC35

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human EML4 recombinant protein (Position: K207-N423) .

Clonality

Polyclonal

Tissue Specificity

High expression in adult thyroid, lower expression in adult and fetal kidney and fetal brain. Not expressed in other tissues.

Applications

Flow Cytometry

Field of Research

Cytoskeleton, Microtubules, Subcellular Markers, Tags & Cell Markers

Purification

Immunogen affinity purified.

Form

Liquid

Function

May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. .

References & Citations

1. Heidebrecht, H. J., Buck, F., Pollmann, M., Siebert, R., Parwaresch, R. Cloning and localization of C2orf2-ropp120, a previously unknown WD repeat protein. Genomics 68: 348-350, 2000. 2. Maddalo, D., Manchado, E., Concepcion, C. P., Bonetti, C., Vidigal, J. A., Han, Y.-C., Ogrodowski, P., Crippa, A., Rekhtman, N., de Stanchina, E., Lowe, S. W., Ventura, A. In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system.Nature 516: 423-427, 2014. Note: Erratum: Nature 524: 502 only, 2015.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

108 kDa

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Echinoderm microtubule associated protein like 4

Subcellular Location

Cytoplasm, cytoskeleton.

Protein Name

Insulin-like growth factor-binding protein 1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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