Anti-CFP Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Properdin (factor P) is a plasma protein that is active in the alternative complement pathway of the innate immune system. It is mapped to Xp11.23. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Synonyms
Properdin; Complement factor P; CFP; PFC
Gene Name
CFP
Gene ID
5199
UniProt
P27918
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human CFP, which shares 86.1% amino acid (aa) sequence identity with both mouse and rat CFP.
Clonality
Polyclonal
Tissue Specificity
Widely expressed.
Applications
Flow Cytometry
Field of Research
Microbiology, Protein
Purification
Immunogen affinity purified.
Form
Liquid
Function
A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes.
References & Citations
1. Ash, S., Johnson, C., Shohat, M., Shohat, T., Schlesinger, M. Further mapping of the properdin deficiency gene in a Tunisian Jewish family--evidence for genetic homogeneity. Isr. J. Med. Sci. 30: 626-628, 1994. 2. Coleman, M. P., Murray, J. C., Willard, H. F., Nolan, K. F., Reid, K. B. M., Blake, D. J., Lindsay, S., Bhattacharya, S. S., Wright, A., Davies, K. E. Genetic and physical mapping around the properdin P gene. Genomics 11: 991-996, 1991.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
55914 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Complement factor properdin
Subcellular Location
Secreted.
Protein Name
Protein argonaute-1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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