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Anti-Calbindin/CALB1 Antibody Picoband® Fluoro550 Conjugated

Product Specifications

Background

Calbindin is a calcium-binding protein belonging to the troponin C superfamily. And it mapped to 8q21.3. Calretinin is expressed in central and peripheral nervous system and in many normal and pathological tissues. The rat and human calretinin exhibit 98% sequence homology and 91% homology to many other species. Two calcium binding proteins, calbindin and calretinin, have been reported to be expressed in abundance in Purkinje cells and other cell types in the cerebellum.

Synonyms

Calbindin; Calbindin D28; D-28K; Vitamin D-dependent calcium-binding protein, avian-type; CALB1; CAB27

Gene Name

CALB1

Gene ID

793

UniProt

P05937

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human Calbindin recombinant protein (Position: A2-N261) .

Clonality

Polyclonal

Tissue Specificity

Detected in skin. In the cornea, it is detected in the epithelial basement membrane, the epithelial cells, and at a lower level in stromal cells. Stratified squamous epithelia. Found in hemidesmosomes. Expressed in cornea, oral mucosa, esophagus, intestine, kidney collecting ducts, ureter, bladder, urethra and thymus but is absent in lung, blood vessels, skeletal muscle and nerves.

Applications

Flow Cytometry

Field of Research

Calcium Binding Proteins, Calcium Signaling, Cell Type Marker, Neuron Marker, Neuroscience, Neurotransmission

Purification

Immunogen affinity purified.

Form

Liquid

Function

Buffers cytosolic calcium. May stimulate a membrane Ca (2+) -ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.

References & Citations

1. Parmentier M.; The human calbindins: cDNA and gene cloning.; Adv. Exp. Med. Biol. 255:233-240 (1989) . 2. Strauss K.I., Kuznicki J., Winsky L., Kawagoe J.I., Hammer M., Jacobowitz D.M.; The mouse calretinin gene promoter region: structural and functional components.; Brain Res. Mol. Brain Res. 49:175-187 (1997) . 3. Gabrielides C., McCormack A.L., Hunt D.F., Christakos S.; Brain calbindin-D28k and an Mr 29,000 calcium binding protein in cerebellum are different but related proteins: evidence obtained from sequence analysis by tandem mass spectrometry.; Biochemistry 30:656-662 (1991) .

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

30,025 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Calbindin 1, 28kDa

Subcellular Location

Hemidesmosome, Membrane, Single-pass type II membrane protein, Basement membrane.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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