Anti-Alpha 1 microglobulin/AMBP Antibody Picoband® Fluoro594 Conjugated
Product Specifications
Background
Protein AMBP is a protein that in humans is encoded by the AMBP gene. This gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a urinary trypsin inhibitor belonging to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. This gene is located on chromosome 9 in a cluster of lipocalin genes.
Synonyms
Protein AMBP; Alpha-1-microglobulin; Protein HC; Alpha-1 microglycoprotein; Complex-forming glycoprotein heterogeneous in charge; Inter-alpha-trypsin inhibitor light chain; ITI-LC; Bikunin; EDC1; HI-30; Uronic-acid-rich protein; Trypstatin; AMBP; HCP; ITIL
Gene Name
AMBP
Gene ID
259
UniProt
P02760
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E. coli-derived human Alpha 1 microglobulin recombinant protein (Position: G20-V203) .
Clonality
Polyclonal
Tissue Specificity
Expressed by the liver and secreted in plasma. Alpha-1-microglobulin occurs in many physiological fluids including plasma, urine, and cerebrospinal fluid. Inter-alpha- trypsin inhibitor is present in plasma and urine.
Applications
Flow Cytometry
Field of Research
Cancer, Cardiovascular, Cell Biology, Protease Inhibitors, Proteolysis/Ubiquitin, Serum Proteins, Tumor Biomarkers
Purification
Immunogen affinity purified.
Form
Liquid
Function
Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization.
References & Citations
1. Entrez Gene: AMBP alpha-1-microglobulin/bikunin precursor. 2. Salier JP, Simon D, Rouet P, Raguenez G, Muscatelli F, Gebhard W, Guenet JL, Mattei MG (Dec 1992) . Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily. Genomics. 14 (1) : 83–8. 3. Vetr H, Gebhard W (Jun 1991) . Structure of the human alpha 1-microglobulin-bikunin gene. Biol. Chem. Hoppe-Seyler. 371 (12) : 1185–96.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Alpha-1-microglobulin
Subcellular Location
Secreted.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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