Anti-Talin 1/TLN1 Antibody Picoband® Fluoro647 Conjugated

Talin-1 is a protein that in humans is encoded by the TLN1 gene. This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin.

A synthetic peptide corresponding to a sequence in the middle region of human Talin 1, which shares 97.6% amino acid (aa) sequence identity with both mouse and rat Talin 1.

Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity) .

1. Ben-Yosef T, Francomano CA (Dec 1999) . Characterization of the human talin (TLN) gene: genomic structure, chromosomal localization, and expression pattern. Genomics. 62 (2) : 316–9. 2. Gilmore AP, Ohanian V, Spurr NK, Critchley DR (Aug 1995) . Localisation of the human gene encoding the cytoskeletal protein talin to chromosome 9p. Human Genetics. 96 (2) : 221–4.