Anti-Smoothelin/SMTN Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Smoothelin is a protein that in humans is encoded by the SMTN gene. This gene encodes a structural protein that is found exclusively in contractile smooth muscle cells. It associates with stress fibers and constitutes part of the cytoskeleton. This gene is localized to chromosome 22q12.3, distal to the TUPLE1 locus and outside the DiGeorge syndrome deletion. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
Synonyms
Smoothelin; SMTN; SMSMO
Gene Name
SMTN
Gene ID
6525
UniProt
P53814
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human Smoothelin, which shares 97.3% amino acid (aa) sequence identity with mouse Smoothelin.
Clonality
Polyclonal
Tissue Specificity
Smooth muscle; contractile or vascular (for the long form) .
Applications
Flow Cytometry
Field of Research
Vasculature
Purification
Immunogen affinity purified.
Form
Liquid
Function
Structural protein of the cytoskeleton.
References & Citations
1. Engelen JJ, Esterling LE, Albrechts JC, Detera-Wadleigh SD, van Eys GJ (Sep 1997) . Assignment of the human gene for smoothelin (SMTN) to chromosome 22q12 by fluorescence in situ hybridization and radiation hybrid mapping. Genomics. 43 (2) : 245–7. 2. van der Loop FT, Schaart G, Timmer ED, Ramaekers FC, van Eys GJ (Sep 1996) . Smoothelin, a novel cytoskeletal protein specific for smooth muscle cells. J Cell Biol. 134 (2) : 401–11.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
56903 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Smoothelin
Subcellular Location
Cytoplasm, cytoskeleton. Exhibits a filamentous organization.
Protein Name
Vesicular acetylcholine transporter
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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