Anti-ANP/Nppa Antibody Picoband®

Atrial natriuretic peptide (ANP), also known as NPPA or PND, is a powerful vasodilator, and a protein (polypeptide) hormone secreted by heart muscle cells. This gene is mapped to 1p36.22. It is involved in the homeostatic control of body water, sodium, potassium and fat (adipose tissue) . ANP is released by muscle cells in the upper chambers (atria) of the heart (atrial myocytes) in response to high blood volume. It acts to reduce the water, sodium and adipose loads on the circulatory system, thereby reducing blood pressure. ANP has exactly the opposite function of the aldosterone secreted by the zona glomerulosa in regard to its effect on sodium in the kidney – that is, aldosterone stimulates sodium retention and it generates sodium loss.

Natriuretic peptides A; Prepronatriodilatin; Atrial natriuretic factor; ANF; Atrial natriuretic peptide; ANP; Auriculin-B; Auriculin-A; Atriopeptin-1; Atriopeptin I; Atriopeptin-2; Atriopeptin II; Nppa; Pnd

Predominantly expressed in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium.

Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

1. Addicks K, Forssmann WG, Henkel H, Holthausen U, Menz V, Rippegather G, Ziskoven D (1989) . Calcium-calmodulin antagonists Influences the release of cardiodilatin/ANP from atrial cardiocytes. In Wambach G, Kaufmann W.Endocrinology of the heart. Berlin: Springer-Verlag. 1. 2. Potter LR, Yoder AR, Flora DR, Antos LK, Dickey DM (2009) . Natriuretic peptides: their structures, receptors, physiologic functions and therapeutic applications. Handb Exp Pharmacol. Handbook of Experimental Pharmacology 191 (191) : 341–66. 3. Widmaier, Eric P.; Hershel Raff; Kevin T. Strang (2008) . Vander's Human Physiology, 11th Ed. McGraw-Hill. pp. 291, 509–10.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.