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Anti-FNDC5 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Fibronectin type III domain-containing protein 5, the precursor of irisin, is a protein that is encoded by the FNDC5 gene. This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants.

Synonyms

Fibronectin type III domain-containing protein 5; Fibronectin type III repeat-containing protein 2; Irisin; FNDC5; FRCP2

Gene Name

FNDC5

Gene ID

252995

UniProt

Q8NAU1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human FNDC5 recombinant protein (Position: D32-E143) .

Clonality

Polyclonal

Tissue Specificity

Widely expressed, with highest levels in heart. Very low expression, if any, in colon, pancreas and spleen.

Applications

Flow Cytometry

Field of Research

Cell Biology, Metabolism, Obesity

Purification

Immunogen affinity purified.

Form

Liquid

Function

Irisin: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue.

References & Citations

1. Erickson HP (October 2013) . Irisin and FNDC5 in retrospect: An exercise hormone or a transmembrane receptor?. Adipocyte. 2 (4) : 289–93. 2. Staiger, H., Bohm, A., Scheler, M., Berti, L., Machann, J., Schick, F., Machicao, F., Fritsche, A., Stefan, N., Weigert, C., Krook, A., Haring, H.-U., de Angelis, M. H. Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning' factor irisin, determines insulin sensitivity. PLoS One 8: e61903, 2013.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Fibronectin type III domain containing 5

Subcellular Location

Cell membrane.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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