Anti-Dermatopontin/DPT Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Dermatopontin is a protein that in humans is encoded by the DPT gene. Dermatopontin is an extracellular matrix protein with possible functions in cell-matrix interactions and matrix assembly. The protein is found in various tissues and many of its tyrosine residues are sulphated. Dermatopontin is postulated to modify the behavior of TGF-beta through interaction with decorin.
Synonyms
Dermatopontin; Tyrosine-rich acidic matrix protein; TRAMP; DPT
Gene Name
DPT
Gene ID
1805
UniProt
Q07507
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E. coli-derived human Dermatopontin recombinant protein (Position: Q19-V201) .
Clonality
Polyclonal
Tissue Specificity
Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta. Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts.
Applications
Flow Cytometry
Field of Research
Biochemicals, Chemical Type, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity) .
References & Citations
1. Entrez Gene: DPT dermatopontin. 2. Kuroda K, Okamoto O, Shinkai H (1999) . Dermatopontin expression is decreased in hypertrophic scar and systemic sclerosis skin fibroblasts and is regulated by transforming growth factor-beta1, interleukin-4, and matrix collagen. J. Invest. Dermatol. 112 (5) : 706–10. 3. Superti-Furga A, Rocchi M, Schafer BW, Gitzelmann R (Oct 1993) . Complementary DNA sequence and chromosomal mapping of a human proteoglycan-binding cell-adhesion protein (dermatopontin) . Genomics. 17 (2) : 463–7.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
33310 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Dermatopontin
Subcellular Location
Secreted, extracellular space, extracellular matrix.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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