Anti-Cathepsin E/CTSE Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Cathepsin E is an enzyme that in humans is encoded by the CTSE gene. This gene encodes a member of the A1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme, an aspartic endopeptidase, may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration.
Synonyms
Cathepsin E; Cathepsin E form I; Cathepsin E form II; CTSE
Gene Name
CTSE
Gene ID
1510
UniProt
P14091
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E. coli-derived human Cathepsin E recombinant protein (Position: A150-R393) .
Clonality
Polyclonal
Tissue Specificity
Expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. Not expressed in resting B- lymphocytes.
Applications
Flow Cytometry
Field of Research
Adaptive Immunity, Immunology, Innate Immunity, Macrophage/Inflammation
Purification
Immunogen affinity purified.
Form
Liquid
Function
May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.
References & Citations
1. Azuma T, Pals G, Mohandas TK, Couvreur JM, Taggart RT (October 1989) . Human gastric cathepsin E. Predicted sequence, localization to chromosome 1, and sequence homology with other aspartic proteinases. The Journal of Biological Chemistry. 264 (28) : 16748–53. 2. Couvreur JM, Azuma T, Miller DA, Rocchi M, Mohandas TK, Boudi FA, Taggart RT (Aug 1990) . Assignment of cathepsin E (CTSE) to human chromosome region 1q31 by in situ hybridization and analysis of somatic cell hybrids. Cytogenetics and Cell Genetics. 53 (2-3) : 137–9.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
35883 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Cathepsin E
Subcellular Location
Endosome.
Protein Name
Annexin A4
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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