Anti-Collagen IV COL4A1 Antibody Picoband® (monoclonal, 3G3)

COL4A1, also known as ICH or Collagen alpha-1 (IV), is a protein that in humans is encoded by the COL4A1 gene. It is mapped to 13q34. This gene encodes the major type IV alpha collagen chain of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. COL4A1 binds to alpha-1/beta-1 integrin and inhibits migration, proliferation, and tube formation by endothelial cells. It is also a potential therapeutic candidate for targeting tumor angiogenesis.

E.coli-derived human Collagen IV recombinant protein (Position: G1445-T1669) . Human Collagen IV shares 97% amino acid (aa) sequence identity with mouse Collagen IV.

Cancer, Collagen, Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Invasion/Microenvironment, Mesenchymal Stem Cells, Signal Transduction, Stem Cells

Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.

1. Soininen R, Haka-Risku T, Prockop DJ, Tryggvason K (Jan 1988) . Complete primary structure of the alpha 1-chain of human basement membrane (type IV) collagen. FEBS Lett 225 (1-2) : 188–94. 2. Plaisier E, Gribouval O, Alamowitch S et al. (2007) . COL4A1 mutations and hereditary angiopathy, nephropathy, aneurysms, and muscle cramps. N. Engl. J. Med. 357 (26) : 2687–2695. 3. Wang, X., Harris, R. E., Bayston, L. J., Ashe, H. L. Type IV collagens regulate BMP signalling in Drosophila. Nature 455: 72-77, 2008.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.