Anti-Tryptophan Hydroxylase/TPH1 Antibody Picoband® Fluoro550 Conjugated
Product Specifications
Background
Tryptophan hydroxylase 1 (TPH1) is an isoenzyme of tryptophan hydroxylase which in humans is encoded by the TPH1 gene. This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.
Synonyms
Tryptophan 5-hydroxylase 1; Tryptophan 5-monooxygenase 1; TPH1; TPH; TPRH; TRPH
Gene Name
TPH1
Gene ID
7166
UniProt
P17752
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E. coli-derived human Tryptophan Hydroxylase recombinant protein (Position: M1-K111) .
Clonality
Polyclonal
Tissue Specificity
Isoform 2 seems to be less widely expressed than isoform 1.
Applications
Flow Cytometry
Field of Research
Amino Acid Metabolism, Amino Acids, Cancer, Cancer Metabolism, Endocrine Metabolism, Energy Metabolism, Energy Transfer Pathways, Hormone Biosynthesis, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Neuroscience, Neurotransmitter, Pathways and Processes, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
References & Citations
1. Entrez Gene: TPH1 tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) . 2. New AS, Gelernter J, Yovell Y, Trestman RL, Nielsen DA, Silverman J, Mitropoulou V, Siever LJ (1998) . Tryptophan hydroxylase genotype is associated with impulsive-aggression measures: a preliminary study. Am. J. Med. Genet. 81 (1) : 13–7.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Tryptophan hydroxylase 1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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