What sizes are available for Anti-RANK/TNFRSF11A Antibody Picoband® Fluoro647 Conjugated?

Anti-RANK/TNFRSF11A Antibody Picoband® Fluoro647 Conjugated is available in the following size(s): 100 µg/Vial.

What buffer is this product supplied in?

The formulation or storage buffer is listed on the product datasheet. If you require a carrier-free or custom formulation, contact us before ordering, as this may involve a made-to-order production timeline.

What dilution range is recommended for immunohistochemistry (IHC) with this antibody?

A starting IHC dilution range is listed on the datasheet, but should be optimized for your specific tissue type and staining protocol.

Can I request a Safety Data Sheet (SDS) for this product?

Yes, safety data sheets are available for hazardous or chemically classified products and can be provided on request or downloaded from the product page.

Anti-RANK/TNFRSF11A Antibody Picoband® Fluoro647 Conjugated

Q: What is the catalog number for Anti-RANK/TNFRSF11A Antibody Picoband® Fluoro647 Conjugated?

The catalog number for Anti-RANK/TNFRSF11A Antibody Picoband® Fluoro647 Conjugated is A01064-2-Fluoro647.

Selected Variant

A01064-2-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

Receptor Activator of Nuclear Factor κ B (RANK), also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is also expressed on dendritic cells and facilitates immune signaling. It is found on the surface of stromal cells, osteoblasts, and T cells. By analysis of somatic cell and radiation hybrid panels, this gene is mapped to 18q22.1.

Synonyms

Tumor necrosis factor receptor superfamily member 11A; Osteoclast differentiation factor receptor; ODFR; Receptor activator of NF-KB; CD265; TNFRSF11A; RANK

Gene Name

TNFRSF11A

Gene ID

8792

UniProt

Q9Y6Q6

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human RANK recombinant protein (Position: C34-L211) .

Clonality

Polyclonal

Tissue Specificity

Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland.

Applications

Flow Cytometry

Field of Research

Adapters, Atherosclerosis, Cardiovascular, Cytokines, Cytoskeleton/ECM, Extracellular Matrix, Growth Factors/Hormones, Immunology, Innate Immunity, Signal Transduction, Structures, TNF Superfamily, Transmembrane, Vascular Inflammation

Purification

Immunogen affinity purified.

Form

Liquid

Function

Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.

References & Citations

1. Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ (1999) . Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr. Rev. 20 (3) : 345–57. 2. Theill LE, Boyle WJ, Penninger JM (2002) . RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annu. Rev. Immunol. 20: 795–823. 3. Wong BR, Josien R, Choi Y (1999) . TRANCE is a TNF family member that regulates dendritic cell and osteoclast function. J. Leukoc. Biol. 65 (6) : 715–24.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

Tumor necrosis factor receptor superfamily, member 11a, NFKB activator

Subcellular Location

Isoform 1: Cell membrane

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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