Anti-StAR Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
The steroidogenic acute regulatory protein, commonly referred to as StAR (STARD1), is a transport protein. This protein plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. It permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13.
Synonyms
Steroidogenic acute regulatory protein, mitochondrial; StAR; START domain-containing protein 1; StARD1; STAR; STARD1
Gene Name
STAR
Gene ID
6770
UniProt
P49675
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human StAR, which shares 85% and 87.5% amino acid (aa) sequence identity with mouse and rat StAR, respectively.
Clonality
Polyclonal
Tissue Specificity
Expressed in gonads, adrenal cortex and kidney.
Applications
Flow Cytometry
Field of Research
Metabolic Signaling Pathways, Metabolism, Metabolism of Lipids and Lipoproteins, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Organelle Proteins, Pathways and Processes, Protein Trafficking, Signal Transduction
Purification
Immunogen affinity purified.
Form
Liquid
Function
Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.
References & Citations
1. Bose HS, Whittal RM, Baldwin MA, Miller WL (June 1999) . The active form of the steroidogenic acute regulatory protein, StAR, appears to be a molten globule. Proc. Natl. Acad. Sci. U.S.A. 96 (13) : 7250–5. 2. Roostaee A, Barbar E, Lehoux JG, Lavigne P (June 2008) . Cholesterol binding is a prerequisite for the activity of the steroidogenic acute regulatory protein (StAR) . Biochem. J. 412 (3) : 553–62.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
25283 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Steroidogenic acute regulatory protein
Subcellular Location
Mitochondrion.
Protein Name
Vascular endothelial growth factor A
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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