Anti-RAB6A Antibody Picoband® Fluoro647 Conjugated

Ras-related protein Rab-6A is a protein that in humans is encoded by the RAB6A gene located in the eleventh chromosome. This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) ions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

A synthetic peptide corresponding to a sequence at the C-terminus of human RAB6A, which shares 97.2% amino acid (aa) sequence identity with both mouse and rat RAB6A.

Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER) . Has a low GTPase activity. Involved in COPI-independent retrograde transport from the Golgi to the ER (PubMed:25962623) .

1. Entrez Gene: RAB6A RAB6A, member RAS oncogene family. 2. Echard A, Opdam FJ, de Leeuw HJ, Jollivet F, Savelkoul P, Hendriks W, Voorberg J, Goud B, Fransen JA (November 2000) . Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms. Mol. Biol. Cell. 11 (11) : 3819–33.