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Anti-PSD Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

PSD, which called EFA6A, is 63% identical to EFA6B (PSD4) and contains a Sec7 domain adjacent to a PH domain, followed by a C-terminal coiled-coil motif. This gene is mapped to chromosome 10q24. And it encodes a Plekstrin homology and SEC7 domains-containing protein that functions as a guanine nucleotide exchange factor. The encoded protein regulates signal transduction by activating ADP-ribosylation factor 6. Alternative splicing results in multiple transcript variants.

Synonyms

PH and SEC7 domain-containing protein 1; Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6; Exchange factor for ARF6; Exchange factor for ARF6 A; Pleckstrin homology and SEC7 domain-containing protein 1; PSD; EFA6, EFA6A

Gene Name

PSD

Gene ID

5662

UniProt

A5PKW4

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human PSD recombinant protein (Position: T536-K803) .

Clonality

Polyclonal

Tissue Specificity

Isoform 2 is expressed in the brain.

Applications

Flow Cytometry

Field of Research

Cytokines, Hematopoietic Progenitors, Immunology, Innate Immunity, Interleukins, Lymphoid, Myeloid, Stem Cells, T Lymphocytic Lineage

Purification

Immunogen affinity purified.

Form

Liquid

Function

Guanine nucleotide exchange factor for ARF6 (PubMed:23603394) . Induces cytoskeletal remodeling (By similarity) .

References & Citations

1. Derrien, V., Couillault, C., Franco, M., Martineau, S., Montcourrier, P., Houlgatte, R., Chavrier, P. A conserved C-terminal domain of EFA6-family ARF6-guanine nucleotide exchange factors induces lengthening of microvilli-like membrane protrusions. J. Cell Sci. 115: 2867-2879, 2002. 2. Perletti, L., Talarico, D., Trecca, D., Ronchetti, D., Fracchiolla, N. S., Maiolo, A. T., Neri, A. Identification of a novel gene, PSD, adjacent to NFKB2/lyt-10, which contains Sec7 and pleckstrin-homology domains. Genomics 46: 251-259, 1997.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

51548 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Pleckstrin and Sec7 domain containing

Subcellular Location

Cell membrane.

Protein Name

Keratin, type II cytoskeletal 8

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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