What sizes are available for Anti-Protein C/PROC Antibody Picoband® Fluoro488 Conjugated?

Anti-Protein C/PROC Antibody Picoband® Fluoro488 Conjugated is available in the following size(s): 100 µg/Vial.

What is the recommended dilution for this antibody?

A recommended dilution range for each validated application is provided on the datasheet, but optimal dilution should be titrated for your specific experimental system, sample type, and detection method.

What is the recommended storage temperature after reconstitution?

Post-reconstitution storage guidance is listed on the datasheet, typically requiring aliquoting and storage at -20°C or -80°C to preserve activity.

Can this product be used in multiplex assays?

Multiplex compatibility depends on the specific product and detection panel. Contact our technical support team with details of your multiplex system for guidance before ordering.

Anti-Protein C/PROC Antibody Picoband® Fluoro488 Conjugated

Q: What is the catalog number for Anti-Protein C/PROC Antibody Picoband® Fluoro488 Conjugated?

The catalog number for Anti-Protein C/PROC Antibody Picoband® Fluoro488 Conjugated is A01742-Fluoro488.

Product Specifications

Background

Protein C (PROC), also called PC, is a zymogenic (inactive) protein, the activated form of which plays an important role in regulating blood clotting, inflammation, cell death and maintaining the permeability of blood vessel walls in humans and other animals. The PROC gene is mapped on 2q14.3. This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.

Synonyms

Vitamin K-dependent protein C; Anticoagulant protein C; Autoprothrombin IIA; Blood coagulation factor XIV; Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide; PROC

Gene Name

PROC

Gene ID

5624

UniProt

P04070

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human Protein C recombinant protein (Position: D200-P461) .

Clonality

Polyclonal

Tissue Specificity

Plasma; synthesized in the liver.

Applications

Flow Cytometry

Field of Research

Collagen, Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265) . Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845) .

References & Citations

1. Allaart, C. F., Poort, S. R., Rosendaal, F. R., Reitsma, P. H., Bertina, R. M., Briet, E. Increased risk of venous thrombosis in carriers of hereditary protein C deficiency defect. Lancet 341: 134-138, 1993. 2. Beckmann, R. J., Schmidt, R. J., Santerre, R. F., Plutzky, J., Crabtree, G. R., Long, G. L. The structure and evolution of a 461 amino acid human protein C precursor and its messenger RNA, based upon the DNA sequence of cloned human liver cDNAs. Nucleic Acids Res. 13: 5233-5247, 1985. 3. Berg, L.-P., Scopes, D. A., Alhaq, A., Kakkar, V. V., Cooper, D. N. Disruption of a binding site for hepatocyte nuclear factor 1 in the protein C gene promoter is associated with hereditary thrombophilia. Hum. Molec. Genet. 3: 2147-2152, 1994.