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Anti-OIF/Ogn Antibody Picoband® Fluoro647 Conjugated

Product Specifications

Background

Osteoglycin (also called mimecan), encoded by the OGN gene, is a human protein. This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor beta and may regulate osteoblast differentiation. High expression of the encoded protein may be associated with elevated heart left ventricular mass.

Synonyms

Mimecan; Osteoglycin; Ogn; Og

Gene Name

Ogn

Gene ID

18295

UniProt

Q62000

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived mouse OIF recombinant protein (Position: A20-F298) .

Clonality

Polyclonal

Tissue Specificity

Expressed in kidney.

Applications

Flow Cytometry

Field of Research

Cell Biology, Cell Cycle, Cell Differentiation, Cytoskeleton/ECM, Extracellular Matrix, Signal Transduction, Structures

Purification

Immunogen affinity purified.

Form

Liquid

Function

Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.

References & Citations

1. Entrez Gene: OGN osteoglycin. 2. Petretto E, Sarwar R, Grieve I, Lu H, Kumaran MK, Muckett PJ, Mangion J, Schroen B, Benson M, Punjabi PP, Prasad SK, Pennell DJ, Kiesewetter C, Tasheva ES, Corpuz LM, Webb MD, Conrad GW, Kurtz TW, Kren V, Fischer J, Hubner N, Pinto YM, Pravenec M, Aitman TJ, Cook SA (May 2008) . Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass. Nat. Genet. 40 (5) : 546–52.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Osteoglycin

Subcellular Location

Secreted, extracellular space, extracellular matrix.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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