1-Dodecylimidazole

1-Dodecylimidazole (N-Dodecylimidazole) is a lysosomotropic detergent and a cytotoxic agent. 1-Dodecylimidazole causes cell death by its acid-dependent accumulation in lysosomes, disruption of the lysosomal membrane, and releaseof cysteine proteases into the cytoplasm. 1-Dodecylimidazole has hypocholesterolaemic activity and broad-spectrum antifungal activity[1][2][3].

Product Specifications

CAS Number

[4303-67-7]

Product Name Alternative

N-Dodecylimidazole

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Fungal

Type

Biochemical Assay Reagents

Related Pathways

Anti-infection

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/1-dodecylimidazole.html

Purity

99.78

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCCCCCCCCCCCN1C=CN=C1

Molecular Formula

C15H28N2

Molecular Weight

236.40

Precautions

H302, H315, H319, H335

References & Citations

[1]Wilson PD, et al. A relationship between multidrug resistance and growth-state dependent cytotoxicity of the lysosomotropic detergent N-dodecylimidazole. Biochem Biophys Res Commun. 1991;176 (3) :1377-1382.|[2]Atkin SD, et al. The isolation of 2,3-oxidosqualene from the liver of rats treated with 1-dodecylimidazole, a novel hypocholesterolaemic agent. Biochem J. 1972;130 (1) :153-157.|[3]Firestone RA, et al. Lysosomotropic agents. 7. Broad-spectrum antifungal activity of lysosomotropic detergents. J Med Chem. 1987;30 (8) :1519-1521.|[4]Boyer MJ, et al. pH dependent cytotoxicity of N-dodecylimidazole: a compound that acquires detergent properties under acidic conditions. Br J Cancer. 1993;67 (1) :81-87.