Anti-LGALS3BP Antibody Picoband®

Galectin-3-binding protein is a protein that in humans is encoded by the LGALS3BP gene. The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV) . It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1.

Galectin-3-binding protein; Basement membrane autoantigen p105; Lectin galactoside-binding soluble 3-binding protein; Mac-2-binding protein; MAC2BP; Mac-2 BP; Tumor-associated antigen 90K; LGALS3BP; M2BP

A synthetic peptide corresponding to a sequence in the middle region of human LGALS3BP, which shares 82.1% and 71.8% amino acid (aa) sequence identity with mouse and rat LGALS3BP, respectively.

1. Entrez Gene: LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein. 2. Calabrese G, Sures I, Pompetti F, Natoli G, Palka G, Iacobelli S (May 1995) . The gene (LGALS3BP) encoding the serum protein 90K, associated with cancer and infection by the human immunodeficiency virus, maps at 17q25. Cytogenet Cell Genet. 69 (3-4) : 223–5.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.