Anti-FRA1/FOSL1 Antibody Picoband® Fluoro647 Conjugated
Selected Variant
A03927-1-Fluoro647
Size: 100 µg/Vial
Product Specifications
Background
Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the FOSL1 gene. The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene.
Synonyms
Fos-related antigen 1; FRA-1; FOSL1; FRA1
Gene Name
FOSL1
Gene ID
8061
UniProt
P15407
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human FRA1, which shares 75.7% and 71.8% amino acid (aa) sequence identity with mouse and rat RA1, respectively.
Clonality
Polyclonal
Tissue Specificity
Adipocytes.
Applications
Flow Cytometry
Field of Research
Domain Families, Epigenetics and Nuclear Signaling, Hlh/Leucine Zipper, Transcription, Transcription Factors
Purification
Immunogen affinity purified.
Form
Liquid
Function
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
References & Citations
1. Entrez Gene: FOSL1 FOS-like antigen 1. 2. Matsui M, Tokuhara M, Konuma Y, Nomura N, Ishizaki R (Mar 1990) . Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation. Oncogene. 5 (3) : 249–55. 3. Pognonec P, Boulukos KE, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H (May 1997) . Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity. Oncogene. 14 (17) : 2091–8.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
FOS like 1, AP-1 transcription factor subunit
Subcellular Location
Nucleus.
Protein Name
Eukaryotic initiation factor 4A-I
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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