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Anti-Annexin VI/ANXA6 Antibody Picoband® Fluoro647 Conjugated

Selected Variant

A03735-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

Annexin A6 (ANXA6) is a member of a family of proteins that bind membrane or cytoskeleton in a Ca (2+) -dependent manner. These proteins are characterized by homologous amino acid sequences that are present in multiple copies in each protein. ANXA6 gene is assigned to 5q32-q34 by use of a cDNA clone to probe genomic DNA from rodent-human somatic cell hybrids and for in situ hybridization. The ANX6 gene is approximately 60 kb long and contains 26 exons. The genomic sequence at the 3-prime end does not contain a canonical polyadenylylation signal. Ca (2+) -dependent binding between CRHSP28 and ANXA6 is required for acinar cell membrane trafficking events and digestive enzyme secretion.

Synonyms

Annexin A6; 67 kDa calelectrin; Annexin VI; Annexin-6; Calphobindin-II; CPB-II; Chromobindin-20; Lipocortin VI; Protein III; p68; p70; ANXA6; ANX6

Gene Name

ANXA6

Gene ID

309

UniProt

P08133

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human Annexin VI recombinant protein (Position: N395-L665) .

Clonality

Polyclonal

Applications

Flow Cytometry

Field of Research

Calcium Binding Proteins, Calcium Signaling, Cell Adhesion, Cytoskeleton/ECM, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Form

Liquid

Function

May associate with CD21. May regulate the release of Ca (2+) from intracellular stores.

References & Citations

1. Davies, A. A., Moss, S. E., Crompton, M. R., Jones, T. A., Spurr, N. K., Sheer, D., Kozak, C., Crumpton, M. J.The gene coding for the p68 calcium-binding protein is localized to bands q32-q34 of human chromosome 5, and to mouse chromosome 11.Hum. Genet. 82: 234-238, 1989. 2. Smith, P. D., Davies, A., Crumpton, M. J., Moss, S. E.Structure of the human annexin VI gene.Proc. Nat. Acad. Sci. 91: 2713-2717, 1994. 3. Thomas, D. D. H., Kaspar, K. M., Taft, W. B., Weng, N., Rodenkirch, L. A., Groblewski, G. E.Identification of annexin VI as a Ca (2+) -sensitive CRHSP-28-binding protein in pancreatic acinar cells.J. Biol. Chem. 277: 35496-35502, 2002.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Annexin A6

Subcellular Location

Cytoplasm. Melanosome

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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