Anti-VAPB Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Vesicle-associated membrane protein-associated protein B/C is a protein that in humans is encoded by the VAPB gene. The VAPB gene is found on the 20th human chromosome. The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking.
Synonyms
Vesicle-associated membrane protein-associated protein B/C; VAMP-B/VAMP-C; VAMP-associated protein B/C; VAP-B/VAP-C; VAPB; UNQ484/PRO983
Gene Name
VAPB
Gene ID
9217
UniProt
O95292
Host
Rabbit
Reactivity
Human, Mouse
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E. coli-derived human VAPB recombinant protein (Position: A2-R55) . Human VAPB shares 98.1% and 100% amino acid (aa) sequence identity with mouse and rat VAPB, respectively.
Clonality
Polyclonal
Tissue Specificity
Ubiquitous. Isoform 1 predominates.
Applications
Flow Cytometry
Field of Research
Cancer, Cancer Metabolism, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism of Lipids and Lipoproteins, Pathways and Processes, Protein Trafficking, Signal Transduction, Vesicle Transport
Purification
Immunogen affinity purified.
Form
Liquid
Function
Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.
References & Citations
1. Entrez Gene: VAPB VAMP (vesicle-associated membrane protein) -associated protein B and C. 2. Nishimura AL, Mitne-Neto M, Silva HC, Richieri-Costa A, Middleton S, Cascio D, Kok F, Oliveira JR, Gillingwater T, Webb J, Skehel P, Zatz M (Nov 2004) . A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis. American Journal of Human Genetics. 75 (5) : 822–31.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
VAMP associated protein B and C
Subcellular Location
Endoplasmic reticulum membrane ; Present in mitochondria-associated membranes that are endoplasmic reticulum membrane regions closely apposed to the outer mitochondrial membrane.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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