What sizes are available for Anti-TPMT Antibody Picoband® Fluoro550 Conjugated?

Anti-TPMT Antibody Picoband® Fluoro550 Conjugated is available in the following size(s): 100 µg/Vial.

Is Anti-TPMT Antibody Picoband® Fluoro550 Conjugated in stock?

Anti-TPMT Antibody Picoband® Fluoro550 Conjugated is currently made to order / not held in immediate stock. Contact us for lead time.

Do you offer custom or private-label production of this type of product?

Yes, custom antibody development and private-label production services are available. Contact our sales team to discuss your target, timeline, and quantity requirements.

What is the immunogen used to generate this antibody?

Immunogen or antigen details used to raise this antibody are listed on the product datasheet under immunogen information.

What is the recommended positive control for this assay?

A recommended positive control, where one is specified by the manufacturer, is listed on the datasheet or in the assay protocol.

Anti-TPMT Antibody Picoband® Fluoro550 Conjugated

Q: What is the catalog number for Anti-TPMT Antibody Picoband® Fluoro550 Conjugated?

The catalog number for Anti-TPMT Antibody Picoband® Fluoro550 Conjugated is A00671-1-Fluoro550.

Selected Variant

A00671-1-Fluoro550

Size: 100 µg/Vial

Product Specifications

Background

Thiopurine methyltransferase or thiopurine S-methyltransferase (TPMT) is an enzyme that in humans is encoded by the TPMT gene. This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.

Synonyms

Thiopurine S-methyltransferase; Thiopurine methyltransferase; TPMT

Gene Name

TPMT

Gene ID

7172

UniProt

P51580

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human TPMT recombinant protein (Position: M1-K245) .

Clonality

Polyclonal

Tissue Specificity

Expressed in natural killer (NK) cells, CD8 (+) alpha-beta and gamma-delta T-cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Expressed in interferon-producing killer dendritic cells (IKDCs) .

Applications

Flow Cytometry

Field of Research

Drug Metabolism, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine.

References & Citations

1. Lee D, Szumlanski C, Houtman J, Honchel R, Rojas K, Overhauser J, Wieben ED, Weinshilboum RM (March 1995) . Thiopurine methyltransferase pharmacogenetics. Cloning of human liver cDNA and a processed pseudogene on human chromosome 18q21.1. Drug Metab. Dispos. 23 (3) : 398–405. 2. Weinshilboum RM, Sladek SL (1980) . Mercaptopurine pharmacogenetics: Monogenic inheritance of erythrocyte thiopurine methyltransferase activity. American Journal of Human Genetics. 32 (5) : 651–662.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

129383 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

Gene Name Synonym

Thiopurine S-methyltransferase

Subcellular Location

Cytoplasm.

Protein Name

Thrombospondin-1

Isotype

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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