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Anti-TPMT Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Thiopurine methyltransferase or thiopurine S-methyltransferase (TPMT) is an enzyme that in humans is encoded by the TPMT gene. This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.

Synonyms

Thiopurine S-methyltransferase; Thiopurine methyltransferase; TPMT

Gene Name

TPMT

Gene ID

7172

UniProt

P51580

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human TPMT recombinant protein (Position: M1-K245) .

Clonality

Polyclonal

Tissue Specificity

Expressed in natural killer (NK) cells, CD8 (+) alpha-beta and gamma-delta T-cells. Expressed on essentially all CD56+CD3- NK cells from freshly isolated PBMC. Expressed in interferon-producing killer dendritic cells (IKDCs) .

Applications

Flow Cytometry

Field of Research

Drug Metabolism, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine.

References & Citations

1. Lee D, Szumlanski C, Houtman J, Honchel R, Rojas K, Overhauser J, Wieben ED, Weinshilboum RM (March 1995) . Thiopurine methyltransferase pharmacogenetics. Cloning of human liver cDNA and a processed pseudogene on human chromosome 18q21.1. Drug Metab. Dispos. 23 (3) : 398–405. 2. Weinshilboum RM, Sladek SL (1980) . Mercaptopurine pharmacogenetics: Monogenic inheritance of erythrocyte thiopurine methyltransferase activity. American Journal of Human Genetics. 32 (5) : 651–662.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

129383 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Thiopurine S-methyltransferase

Subcellular Location

Cytoplasm.

Protein Name

Thrombospondin-1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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