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Anti-BAFF Receptor/TNFRSF13C Antibody Picoband® Fluoro488 Conjugated

Selected Variant

A02865-1-Fluoro488

Size: 100 µg/Vial

Product Specifications

Background

Tumor necrosis factor receptor superfamily member 13C (TNFRSF13C), also known as BAFFR, is a protein in humans is encoded by the TNFRSF13C gene. The BAFFR gene is mapped to chromosome 22q13.1-q13.31. It has got 184 amino acid transmembrane protein which is 56% identical to the mouse protein. B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. BAFF plays a crucial role in B cell development and can function through receptors other than BCMA.

Synonyms

Tumor necrosis factor receptor superfamily member 13C; B-cell-activating factor receptor; BAFF receptor; BAFF-R; BLyS receptor 3; CD268; TNFRSF13C; BAFFR; BR3

Gene Name

TNFRSF13C

Gene ID

115650

UniProt

Q96RJ3

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human BAFF Receptor recombinant protein (Position: M1-L78) .

Clonality

Polyclonal

Tissue Specificity

Highly expressed in spleen and lymph node, and in resting B-cells. Detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes.

Applications

Flow Cytometry

Field of Research

Growth Factors/Hormones, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.

References & Citations

1. Thompson JS, Bixler SA, Qian F, Vora K, Scott ML, Cachero TG, Hession C, Schneider P, Sizing ID, Mullen C, Strauch K, Zafari M, Benjamin CD, Tschopp J, Browning JL, Ambrose C (Sep 2001) . BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. Science 293 (5537) : 2108–11. 2. “Entrez Gene: TNFRSF13C tumor necrosis factor receptor superfamily, member 13C. 3. Schiemann, B., Gommerman, J. L., Vora, K., Cachero, T. G., Shulga-Morskaya, S., Dobles, M., Frew, E., Scott, M. L.An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway.Science293: 2111-2114, 2001.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Tumor necrosis factor receptor superfamily, member 13C

Subcellular Location

Membrane; Single-pass type III membrane protein.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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