Anti-TACI/TNFRSF13B Antibody Fluoro647 Conjugated
Product Specifications
Background
Transmembrane activator and CAML interactor (TACI), also known as tumor necrosis factor receptor superfamily member 13B (TNFRSF13B) is a protein that in humans is encoded by the TNFRSF13B gene. The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML) . The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17.
Synonyms
Tumor necrosis factor receptor superfamily member 13B; Transmembrane activator and CAML interactor; CD267; TNFRSF13B; TACI
Gene Name
TNFRSF13B
Gene ID
23495
UniProt
O14836
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E. coli-derived human TACI recombinant protein (Position: M1-S165) .
Clonality
Polyclonal
Tissue Specificity
Highly expressed in spleen, thymus, small intestine and peripheral blood leukocytes. Expressed in resting B- cells and activated T-cells, but not in resting T-cells.
Applications
Flow Cytometry
Field of Research
Apoptosis, Apoptotic Markers, Cancer, Caspases, Cell Biology, Cell Death, Intracellular, Invasion/Microenvironment, Metabolism, Metabolism Processes, Pathways and Processes
Purification
Immunogen affinity purified.
Form
Liquid
Function
Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T- cell function and the regulation of humoral immunity.
References & Citations
1. Entrez Gene: TNFRSF13B tumor necrosis factor receptor superfamily, member 13B. 2. Seshasayee D, Valdez P, Yan M, Dixit VM, Tumas D, Grewal IS (February 2003) . Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor. Immunity. 18 (2) : 279–88.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
79686 MW
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
TNF receptor superfamily member 13B
Subcellular Location
Membrane; Single-pass type III membrane protein.
Protein Name
Peroxisomal multifunctional enzyme type 2
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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