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Anti-SLC31A1/CTR1 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

High affinity copper uptake protein 1 (Ctr1) is a protein that in humans is encoded by the SLC31A1 gene. This gene is maped to 9q32. The protein encoded by this gene is a high-affinity copper transporter found in the cell membrane. The encoded protein functions as a homotrimer to effect the uptake of dietary copper.

Synonyms

High affinity copper uptake protein 1; Copper transporter 1; hCTR1; Solute carrier family 31 member 1; SLC31A1; COPT1; CTR1

Gene Name

SLC31A1

Gene ID

1317

UniProt

O15431

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human SLC31A1/CTR1, identical to the related mouse and rat sequences.

Clonality

Polyclonal

Tissue Specificity

Found in the synovial fluid of patients with rheumatoid arthritis. .

Applications

Flow Cytometry

Field of Research

Neuroscience, Neurotransmission, Receptors / Channels

Purification

Immunogen affinity purified.

Form

Liquid

Function

High-affinity, saturable copper transporter involved in dietary copper uptake.

References & Citations

1. Eisses, J. F., Kaplan, J. H. Molecular characterization of hCTR1, the human copper uptake protein. J. Biol. Chem. 277: 29162-29171, 2002. 2. Klomp, A. E. M., Tops, B. B. J., van den Berg, I. E. T., Berger, R., Klomp, L. W. J. Biochemical characterization and subcellular localization of human copper transporter 1 (hCTR1) . Biochem. J. 364: 497-505, 2002. 3. Kuo, Y.-M., Zhou, B., Cosco, D., Gitschier, J. The copper transporter CTR1 provides an essential function in mammalian embryonic development. Proc. Nat. Acad. Sci. 98: 6836-6841, 2001.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

31203 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Solute carrier family 31 member 1

Subcellular Location

Cell membrane; Localizes to the apical membrane in intestinal epithelial cells.

Protein Name

Tumor necrosis factor-inducible gene 6 protein

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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