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Anti-SLC26A4 Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Pendrin, is an anion exchange protein that in humans is encoded by the SLC26A4 gene. Pendrin is an ion exchanger found in many types of cells in the body. High levels of pendrin expression have been identified in the inner ear and thyroid. In the thyroid, pendrin mediates a component of the efflux of iodide across the apical membrane of the thyrocyte, which is critical for the formation of thyroid hormone. The exact function of pendrin in the inner ear remains unclear; however, pendrin may play a role in acid-base balance as a chloride-bicarbonate exchanger, regulate volume homeostasis through its ability to function as a chloride-formate exchanger or inly modulate the calcium concentration of the endolymph.

Synonyms

Pendrin; Sodium-independent chloride/iodide transporter; Solute carrier family 26 member 4; SLC26A4; PDS

Gene Name

SLC26A4

Gene ID

5172

UniProt

O43511

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human SLC26A4, which shares 84.4% amino acid (aa) sequence identity with both mouse and rat SCNN1A.

Clonality

Polyclonal

Tissue Specificity

High expression in adult thyroid, lower expression in adult and fetal kidney and fetal brain. Not expressed in other tissues.

Applications

Flow Cytometry

Field of Research

Cancer, Cofactors, Vitamins/Minerals, Metabolism, Neuroscience, Neurotransmission, Neurotransmitter, Pathways and Processes, Plasma Membrane, Receptors / Channels, Sensory System, Signal Transduction, Transporters, Vitamins/Minerals

Purification

Immunogen affinity purified.

Form

Liquid

Function

Sodium-independent transporter of chloride and iodide.

References & Citations

1. Entrez Gene: SLC26A4 solute carrier family 26, member 4. 2. Scott DA, Wang R, Kreman TM, Sheffield VC, Karniski LP (April 1999) . The Pendred syndrome gene encodes a chloride-iodide transport protein. Nature Genetics. 21 (4) : 440–3. 3. Wall SM (2006) . The renal physiology of pendrin (SLC26A4) and its role in hypertension. Novartis Foundation Symposium. Novartis Foundation Symposia. 273: 231–9; discussion 239–43, 261–4.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Solute carrier family 26 member 4

Subcellular Location

Membrane; Localizes to the apical brush border of cells in the cortical collecting ducts of the kidney.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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