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Anti-SLC26A4 Antibody Picoband®

Boster Bio Anti-SLC26A4 Antibody Picoband® catalog # A00919-1. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Pendrin, is an anion exchange protein that in humans is encoded by the SLC26A4 gene. Pendrin is an ion exchanger found in many types of cells in the body. High levels of pendrin expression have been identified in the inner ear and thyroid. In the thyroid, pendrin mediates a component of the efflux of iodide across the apical membrane of the thyrocyte, which is critical for the formation of thyroid hormone. The exact function of pendrin in the inner ear remains unclear; however, pendrin may play a role in acid-base balance as a chloride-bicarbonate exchanger, regulate volume homeostasis through its ability to function as a chloride-formate exchanger or inly modulate the calcium concentration of the endolymph.

Synonyms

Pendrin; Sodium-independent chloride/iodide transporter; Solute carrier family 26 member 4; SLC26A4; PDS

Gene Name

SLC26A4

Gene ID

5172

UniProt

O43511

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human SLC26A4, which shares 84.4% amino acid (aa) sequence identity with both mouse and rat SCNN1A.

Clonality

Polyclonal

Tissue Specificity

High expression in adult thyroid, lower expression in adult and fetal kidney and fetal brain. Not expressed in other tissues.

Applications

WB

Field of Research

Cancer, Cofactors, Vitamins/Minerals, Metabolism, Neuroscience, Neurotransmission, Neurotransmitter, Pathways and Processes, Plasma Membrane, Receptors / Channels, Sensory System, Signal Transduction, Transporters, Vitamins/Minerals

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Sodium-independent transporter of chloride and iodide.

References & Citations

1. Entrez Gene: SLC26A4 solute carrier family 26, member 4. 2. Scott DA, Wang R, Kreman TM, Sheffield VC, Karniski LP (April 1999) . The Pendred syndrome gene encodes a chloride-iodide transport protein. Nature Genetics. 21 (4) : 440–3. 3. Wall SM (2006) . The renal physiology of pendrin (SLC26A4) and its role in hypertension. Novartis Foundation Symposium. Novartis Foundation Symposia. 273: 231–9; discussion 239–43, 261–4.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

86 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Solute carrier family 26 member 4

Subcellular Location

Membrane; Localizes to the apical brush border of cells in the cortical collecting ducts of the kidney.

Isotype

Rabbit IgG

Contents

243

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