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Anti-SCRIBBLE Antibody Picoband® Fluoro550 Conjugated

Product Specifications

Background

SCRIB, also known as Scribble, SCRIBL, or Scribbled homolog (Drosophila), is a scaffold protein which in humans is encoded by the SCRIB gene. In Drosophila melanogaster, SCRIB is involved in synaptic function, neuroblast differentiation, and epithelial polarization. Mechanistically, the human homolog is a scaffold protein linked to cellular differentiation centered on the regulation of epithelial as well as neuronal morphogenesis. Deficiency in SCRIB impairs many aspects of cell polarity and cell movement. SCRIB is also likely involved in establishing apical-basal polarity as well as progression from the G1 phase to S phase in the cell cycle as a result of its relationship with cell proliferation and exocytosis.

Synonyms

Protein scribble homolog; Scribble; hScrib; Protein LAP4; SCRIB; CRIB1; KIAA0147; LAP4; SCRB1; VARTUL

Gene Name

SCRIB

Gene ID

23513

UniProt

Q14160

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human SCRIBBLE recombinant protein (Position: F172-K409) .

Clonality

Polyclonal

Tissue Specificity

Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level) .

Applications

Flow Cytometry

Field of Research

Microbiology

Purification

Immunogen affinity purified.

Form

Liquid

Function

Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.

References & Citations

1. L E Dow; J S Kauffman; J Caddy; A S Peterson; S M Jane; S M Russell & P O Humbert (April 2007) . The tumour-suppressor Scribble dictates cell polarity during ed epithelial migration: regulation of Rho GTPase recruitment to the leading edge. Oncogene. 26 (16) : 2272–82. 2. Yi Qin; Christopher Capaldo; Barry M. Gumbiner & Ian G. Macara (December 2005) . The mammalian SCRIB polarity protein regulates epithelial cell adhesion and migration through E-cadherin. JCB. 171 (6) : 1061–71.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

50514 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Scribbled planar cell polarity protein

Subcellular Location

Cell membrane.

Protein Name

Carboxypeptidase M

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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