Anti-Regucalcin/RGN Antibody Picoband® Fluoro488 Conjugated
Product Specifications
Background
Regucalcin is a protein that in humans is encoded by the RGN gene. The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23.
Synonyms
Regucalcin; RC; Gluconolactonase; GNL; Senescence marker protein 30; SMP-30; RGN; SMP30
Gene Name
RGN
Gene ID
9104
UniProt
Q15493
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human Regucalcin, which shares 87.5% and 84.4% amino acid (aa) sequence identity with mouse and rat Regucalcin, respectively.
Clonality
Polyclonal
Applications
Flow Cytometry
Field of Research
Cell Biology, Cell Cycle, Cell Differentiation, G Protein Signaling, Regulators, Signal Transduction, Signaling Pathway, Small G Proteins
Purification
Immunogen affinity purified.
Form
Liquid
Function
Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro) . Calcium-binding protein. Modulates Ca (2+) signaling, and Ca (2+) -dependent cellular processes and enzyme activities (By similarity) . .
References & Citations
1. Entrez Gene: RGN regucalcin (senescence marker protein-30) . 2. Yamaguchi M (March 2005) . Role of regucalcin in maintaining cell homeostasis and function (review) . International Journal of Molecular Medicine. 15 (3) : 371–89.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Regucalcin
Subcellular Location
Cytoplasm.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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