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Anti-Regucalcin/RGN Antibody Picoband®

Boster Bio Anti-Regucalcin/RGN Antibody Picoband® catalog # A05900-1. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

Regucalcin is a protein that in humans is encoded by the RGN gene. The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23.

Synonyms

Regucalcin; RC; Gluconolactonase; GNL; Senescence marker protein 30; SMP-30; RGN; SMP30

Gene Name

RGN

Gene ID

9104

UniProt

Q15493

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human Regucalcin, which shares 87.5% and 84.4% amino acid (aa) sequence identity with mouse and rat Regucalcin, respectively.

Clonality

Polyclonal

Applications

IHC, WB

Field of Research

Cell Biology, Cell Cycle, Cell Differentiation, G Protein Signaling, Regulators, Signal Transduction, Signaling Pathway, Small G Proteins

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro) . Calcium-binding protein. Modulates Ca (2+) signaling, and Ca (2+) -dependent cellular processes and enzyme activities (By similarity) . .

References & Citations

1. Entrez Gene: RGN regucalcin (senescence marker protein-30) . 2. Yamaguchi M (March 2005) . Role of regucalcin in maintaining cell homeostasis and function (review) . International Journal of Molecular Medicine. 15 (3) : 371–89.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

33 kDa, 43 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Regucalcin

Subcellular Location

Cytoplasm.

Isotype

Rabbit IgG

Contents

243

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