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Anti-PLA2G6 Antibody Picoband®

Boster Bio Anti-PLA2G6 Antibody Picoband® catalog # A01648-1. Tested in ELISA, ICC/IF, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

85 kDa calcium-independent phospholipase A2 is an enzyme that in humans is encoded by the PLA2G6 gene. The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date.

Synonyms

85/88 kDa calcium-independent phospholipase A2; CaI-PLA2; Group VI phospholipase A2; GVI PLA2; Intracellular membrane-associated calcium-independent phospholipase A2 beta; iPLA2-beta; Patatin-like phospholipase domain-containing protein 9; PNPLA9; PLA2G6; PLPLA9

Gene Name

PLA2G6

Gene ID

8398

UniProt

O60733

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human PLA2G6 recombinant protein (Position: W715-L802) .

Clonality

Polyclonal

Tissue Specificity

Four different transcripts were found to be expressed in a distinct tissue distribution.

Applications

ELISA, ICC/IF, WB

Field of Research

Lipid Signaling, Signal Transduction, Signaling Pathway

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and ionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F- actin polymerization at the pseudopods.

References & Citations

1. Entrez Gene: PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) . 2. Larsson PK, Claesson HE, Kennedy BP (Jan 1998) . Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity. The Journal of Biological Chemistry. 273 (1) : 207–14. 3. Wilson PA, Gardner SD, Lambie NM, Commans SA, Crowther DJ (Sep 2006) . Characterization of the human patatin-like phospholipase family. Journal of Lipid Research. 47 (9) : 1940–9.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Calculated Molecular Weight

90 kDa

Observed Molecular Weight

84 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Phospholipase A2 group VI

Subcellular Location

Isoform LH-iPLA2: Membrane; Recruited to the membrane-enriched pseudopod upon MCP1/CCL2 stimulation in monocytes.

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

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