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Anti-Mitochondrial Pyruvate dehydrogenase kinase 1/PDK1 Antibody Picoband® Fluoro647 Conjugated

Selected Variant

A01268-1-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

PDK1 (Pyruvate Dehydrogenase Kinase Isoenzyme 1), is an enzyme that in humans is encoded by the PDK1 gene. To find human PDKs, Gudi et al. (1995) used oligonucleotide primers to screen a human liver cDNA library by PCR. They identified and reported the deduced amino acid sequences of PDK1, PDK2, and PDK3. The human PDK1 gene encodes a protein with a predicted molecular mass of 49,244 Da that shares 93% identity with that of the rat PDK1 gene. Northern blot analysis showed that the PDK1 message was expressed predominantly in the heart.

Synonyms

[Pyruvate dehydrogenase (acetyl-transferring) ] kinase isozyme 1, mitochondrial; Pyruvate dehydrogenase kinase isoform 1; PDH kinase 1; PDK1; PDHK1

Gene Name

PDK1

Gene ID

5163

UniProt

Q15118

Host

Rabbit

Reactivity

Human, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human PDK1 recombinant protein (Position: V107-Y336) .

Clonality

Polyclonal

Tissue Specificity

Expressed predominantly in the heart. Detected at lower levels in liver, skeletal muscle and pancreas.

Applications

Flow Cytometry

Field of Research

Metabolism, Metabolism Of Carbohydrates, Methylation, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Oncoproteins/Suppressors, Pathways and Processes, Signal Transduction, Tumor Suppressors

Purification

Immunogen affinity purified.

Form

Liquid

Function

Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.

References & Citations

1. Gudi, R., Bowker-Kinley, M. M., Kedishvili, N. Y., Zhao, Y., Popov, K. M. Diversity of the pyruvate dehydrogenase kinase gene family in humans. J. Biol. Chem. 270: 28989-28994, 1995.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

10044 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Pyruvate dehydrogenase kinase, isozyme 1

Subcellular Location

Mitochondrion matrix.

Protein Name

Acyl-CoA-binding protein

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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