Anti-Myelin Protein Zero/MPZ Antibody Picoband® Fluoro488 Conjugated

Myelin protein zero (P0, MPZ) is a glycoprotein which in humans is encoded by the MPZ gene. This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy (CHN) . A recent study showed that two isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism.

Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction.

1. Lemke G, Axel R (March 1985) . Isolation and sequence of a cDNA encoding the major structural protein of peripheral myelin. Cell. 40 (3) : 501–8. 2. Sakamoto Y, Kitamura K, Yoshimura K, Nishijima T, Uyemura K (March 1987) . Complete amino acid sequence of P0 protein in bovine peripheral nerve myelin. J. Biol. Chem. 262 (9) : 4208–14.