Anti-Lactoferrin/LTF Antibody Picoband® Fluoro647 Conjugated
Product Specifications
Background
Lactoferrin (LF), also known as lactotransferrin (LTF), is a multifunctional protein of the transferrin family. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Antimicrobial, antiviral, antifungal and antiparasitic activity has been found for this protein and its peptides.
Synonyms
Lactotransferrin; Lactoferrin; Growth-inhibiting protein 12; Talalactoferrin; Lactoferricin-H; Lfcin-H; Kaliocin-1; Lactoferroxin-A; Lactoferroxin-B; Lactoferroxin-C; LTF; GIG12; LF
Gene Name
LTF
Gene ID
4057
UniProt
P02788
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins.
Immunogen
E. coli-derived human Lactoferrin recombinant protein (Position: D529-K710) .
Clonality
Polyclonal
Tissue Specificity
High levels are found in saliva and tears, intermediate levels in serum and plasma, and low levels in urine. In kidney, detected in the distal collecting tubules in the medulla but not in the cortical region or in blood vessels. Detected in peripheral blood neutrophils (at protein level) . Isoform 1 and isoform DeltaLf are expressed in breast, prostate, spleen, pancreas, kidney, small intestine, lung, skeletal muscle, uterus, thymus and fetal liver. Isoform 1 is expressed in brain, testis and peripheral blood leukocytes; isoform DeltaLf is barely detectable in these tissues. Isoform DeltaLf is expressed in placenta, liver and ovary; isoform 1 is barely detectable in these tissues. In kidney, isoform 1 is expressed at high levels in the collecting tubules of the medulla but at very low levels in the cortex.
Applications
Flow Cytometry
Field of Research
Cardiovascular, Cell Death, Invasion/Microenvironment, Serum Proteins
Purification
Immunogen affinity purified.
Form
Liquid
Function
Transferrins are iron binding transport proteins which can bind two Fe (3+) ions in association with the binding of an anion, usually bicarbonate.
References & Citations
1. Jing-Fen Kang; Xiang-Long Li; Rong-Yan Zhou; Lan-Hui Li; Fu-Jun Feng; Xiu -Li Guo (2008) . Bioinformatics Analysis of Lactoferrin Gene for Several Species. Biochemical Genetics. 46 (5–6) : 312–322. 2. Sánchez L, Calvo M, Brock JH (1992) . Biological role of lactoferrin. Arch. Dis. Child. 67 (5) : 657–61.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
78 kDa
Specificity
No cross reactivity with other proteins.
Applications Notes
6
Gene Name Synonym
Lactotransferrin
Subcellular Location
Isoform 1: Secreted. Cytoplasmic granule. Secreted into most exocrine fluids by various endothelial cells. Stored in the secondary granules of neutrophils.
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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