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Anti-Glutathione Reductase/GSR Antibody Picoband® Fluoro647 Conjugated

Selected Variant

A01479-1-Fluoro647

Size: 100 µg/Vial

Product Specifications

Background

Glutathione reductase (GR), also known as glutathione-disulfide reductase (GSR), is an enzyme that in humans is encoded by the GSR gene. This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found.

Synonyms

Glutathione reductase, mitochondrial; GR; GRase; GSR; GLUR; GRD1

Gene Name

GSR

Gene ID

2936

UniProt

P00390

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross reactivity with other proteins.

Immunogen

E. coli-derived human Glutathione Reductase recombinant protein (Position: K256-R522) .

Clonality

Polyclonal

Tissue Specificity

Expressed in peripheral blood leukocytes.

Applications

Flow Cytometry

Field of Research

Cancer, Cell Biology, Metabolism, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Oxidative Stress, Pathways and Processes, Redox Metabolism, Signal Transduction

Purification

Immunogen affinity purified.

Form

Liquid

Function

Maintains high levels of reduced glutathione in the cytosol.

References & Citations

1. Deponte M (May 2013) . Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes. Biochim. Biophys. Acta. 1830 (5) : 3217–66. 2. Meister A (November 1988) . Glutathione metabolism and its selective modification. J. Biol. Chem. 263 (33) : 17205–8.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

38747 MW

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Glutathione-disulfide reductase

Subcellular Location

Isoform Mitochondrial: Mitochondrion.

Protein Name

Heterogeneous nuclear ribonucleoprotein A1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

Price

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