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Anti-GNS Antibody Picoband®

Boster Bio Anti-GNS Antibody Picoband® catalog # A00999-1. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

N-acetylglucosamine-6-sulfatase, also known as glucosamine (N-acetyl) -6-sulfatase, is an enzyme that in humans is encoded by the GNS gene. The product of this gene is a lysosomal enzyme found in all cells. It is involved in the catabolism of heparin, heparan sulphate, and keratan sulphate. Deficiency of this enzyme results in the accumulation of undegraded substrate and the lysosomal storage disorder mucopolysaccharidosis type IIID (Sanfilippo D syndrome) . Mucopolysaccharidosis type IIID is the least common of the four subtypes of Sanfilippo syndrome.

Synonyms

N-acetylglucosamine-6-sulfatase; Glucosamine-6-sulfatase; G6S; GNS

Gene Name

GNS

Gene ID

2799

UniProt

P15586

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human GNS recombinant protein (Position: W238-R355) .

Clonality

Polyclonal

Tissue Specificity

Found only in peripheral nervous system Schwann cells.

Applications

ELISA, WB

Field of Research

Amino Acid Metabolism, Amino Acids, Cell Biology, Metabolic Signaling Pathways, Metabolism, Organelles, Pathways and Processes, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction, Subcellular Markers, Tags & Cell Markers

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Function

Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs. Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells.

References & Citations

1. Entrez Gene: Glucosamine (N-acetyl) -6-sulfatase. 2. Basner R, Kresse H, von Figura K (February 1979) . N-Acetylglucosamine-6-sulfate sulfatase from human urine. J. Biol. Chem. 254 (4) : 1151–8. 3. Kresse H, Fuchs W, Glössl J, Holtfrerich D, Gilberg W (December 1981) . N-acetylglucosamine-6-sulfate by human β-N-acetylhexosaminidase A. J. Biol. Chem. 256 (24) : 12926–32.

Storage Conditions

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

90 kDa

Specificity

No cross reactivity with other proteins.

Gene Name Synonym

Glucosamine (N-acetyl) -6-sulfatase

Subcellular Location

Lysosome.

Protein Name

D (4) dopamine receptor

Isotype

Rabbit IgG

Contents

243

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