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Anti-GDA Antibody Picoband® Fluoro488 Conjugated

Product Specifications

Background

Guanine deaminase also known as cypin, guanase, guanine aminase, GAH, and guanine aminohydrolase is an aminohydrolase enzyme which converts guanine to xanthine. This gene is mapped to 9q21.13. Studies in rat ortholog suggest this gene plays a role in microtubule assembly. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms

Guanine deaminase; Guanase; Guanine aminase; Guanine aminohydrolase; GAH; p51-nedasin; GDA; KIAA1258

Gene Name

GDA

Gene ID

9615

UniProt

Q9Y2T3

Host

Rabbit

Reactivity

Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins.

Immunogen

E. coli-derived human GDA recombinant protein (Position: E220-Q446) .

Clonality

Polyclonal

Tissue Specificity

Expressed in lung carcinoma cell lines but not in normal lung tissues.

Applications

Flow Cytometry

Field of Research

Chromatin Modifying Enzymes, DNA/Nucleotides, DNA/RNA, Epigenetics and Nuclear Signaling

Purification

Immunogen affinity purified.

Form

Liquid

Function

Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. .

References & Citations

1. Akum, B. F., Chen, M., Gunderson, S. I., Riefler, G. M., Scerri-Hansen, M. M., Firestein, B. L. Cypin regulates dendrite patterning in hippocampal neurons by promoting microtubule assembly. Nature Neurosci. 7: 145-152, 2004. 2. Yuan, G., Bin, J. C., McKay, D. J., Snyder, F. F. Cloning and characterization of human guanine deaminase: purification and partial amino acid sequence of the mouse protein. J. Biol. Chem. 274: 8175-8180, 1999.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Specificity

No cross reactivity with other proteins.

Applications Notes

6

Gene Name Synonym

Guanine deaminase

Subcellular Location

Nucleus.

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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